二、理化性质:在常温常压下是一种无色、有轻微醚类气味的气体;熔点-103.15℃,沸点-26.1℃,液体密度1.206g/cm3(25℃); 一般情况下均压缩成液态储存于钢瓶中,其热力性能与R12相似。臭氧减损潜能值(ODP)为0,全球变暖潜能值(GWP)为1200。
1,1,1,2-四氟乙烷是CFCs喷射剂的主要替代品,同时,由于它的低毒和不易燃性,被研制用于药物吸入剂的载体(即医用气雾剂)。用于治疗哮喘、COPD(慢性阻塞性肺病)和呼吸道感染的防治哮喘气雾剂; 用于治疗过敏性鼻炎的鼻用气雾剂 泡沫气雾剂;口腔与局部气雾剂(如:促进神经感受性,增强牙齿活力和舒缓疼痛)等。
高分子多孔微球填充柱应用之药用辅料1,1,1,2-四氟乙烷 谱图:



1,1,1,2-Tetrafluoroethane as a pharmaceutical excipient for polymer porous microsphere filled column
Details of 1,1,1,2-tetrafluoroethane as a pharmaceutical excipient for the application of polymer porous microsphere filled column:
Pharmaceutical excipient tetrafluoroethane (HFC-134a)
1、 Basic information
Product name: medicinal excipient 1,1,1,2-tetrafluoroethane
Molecular formula: CH2FCF3
Relative molecular weight: 102.03
Product standard: G/JHGF O1 J 20 209-2012
2、 Physical and chemical properties: it is a colorless gas with slight ether odor under normal temperature and pressure; Melting point - 103.15 ℃, boiling point - 26.1 ℃, liquid density 1.206g/cm3 (25 ℃); Generally, they are compressed into liquid and stored in steel cylinders, and their thermal properties are similar to R12. Ozone depletion potential (ODP) is 0, and global warming potential (GWP) is 1200.
3、 Product use:
1,1,1,2-tetrafluoroethane is the main substitute for CFCs sprays. At the same time, due to its low toxicity and non-flammability, it has been developed as a carrier for drug inhalers (i.e. medical aerosols). Anti-asthmatic aerosol used to treat asthma, COPD (chro
nic obstructive pulmo
nary disease) and respiratory tract infection; Nasal aerosol foam aerosol for treating allergic rhinitis; Oral and local aerosols (such as promoting neurosensitivity, enhancing tooth vitality and relieving pain), etc.
Haohan Chromatography (Shandong) Applied Technology Development Co., Ltd. used gas chromatography to determine non-co
ndensable gas in 1,1,1,2-tetrafluoroethane (HFC-134a) in Chinese Pharmacopoeia 2020, with high column efficiency, good separation and satisfactory results.
Name: Filled Column
Statio
nary phase: divinylbenzene-ethylvinylbenzene polymer porous microspheres
Specification: 2m * 3mm
Particle size: 0.18-0.25mm
Application: determination of non-co
ndensable gas in tetrafluoroethane in Chinese Pharmacopoeia 2020
Spectrogram of 1,1,1,2-tetrafluoroethane, a pharmaceutical excipient used in polymer porous microsphere filled column: